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Blog

Potential Treatment for Coronavirus-19

March 15, 2020 7:34 pm

There are a number of possible medications (Hydroxychloroquine and Azithromycin) being reported in the literature. They are mostly small series and not proven scientifically. Some of the medications that are being discussed in the media in fact have significant and deadly side effects. The use of these medications should be avoided until and unless some preliminary data shows any improvement. There are numerous pathways and approaches being considered for both vaccines and medications for the treatment of Coronavirus-19. One of the approaches is to try to minimize and mute the inflammation that is caused by the virus entering the lung cells leading to destructive damage of the lung tissue. There are a number of medications in this class, however, most of them have significant side effects. Baricitinib, a medication currently available for the treatment of rheumatoid arthritis may be such a molecule.

Stapled Anastomosis

December 30, 2019 11:23 am

As I was looking over old archives, I came across the following pictures that were taken years ago. These were photographs taken to demonstrate the technique for the construction of the anastomosis of the biliopancreatic channel and alimentary channel of the Duodenal Switch.

The steps of doing the stapled anastomosis of the Duodenal Switch is generally unchanged during the laparoscopic approach to the procedure.

The fist step is to align the bowel to be joined.

The stitches are placed to secure the bowel together. Two small openings are made in each limb of the bowel to be stapled together (the biliopancreatic limb on the  bottom and the alimentary on the top of the image).

It is important to also align the bowel in the same peristalsis direction. This means that the contraction and the relaxation motion of the bowel should all point in the same direction. This should reduce the risk of complications such as intussusception.

The stapler is then fired in opposite directions to create wide anastomosis.

When the stapler is fired in opposite direction, a very wide anastomosis is created.

 

Closure
Closing the opening that was made

Once the anastomosis is created, then the last staple is used to close the opening that was made. This staple line is perpendicular to the direction of the anastomosis to avoid making the opening narrow.

We originally published this technique in 2003 on Obesity Surgery Journal.

Long Term Health Implications of PPI Use, Antacids

November 19, 2019 12:38 pm

The FDA had initially approved almost all PPI’s, and antacids with an explicit limit placed on the duration of the therapy, which ranged in days to weeks. At that time there were no long term studies done on the health benefits, or side effects of the long term use of the PPI.

This Summary Letter outlines all the concerns dating back to 2011. I have found the information in this letter a good overview of the supporting medical evidence and lack of any long term data in regards to long term PPI.

The FDA made changes in the Black Box warning of the PPI medications.  This was done with the mounting evidence and the health concerns of long term PPI use.

PPI’s have been shown to have detrimental long term side effects. It is prudent that a patient is continuously monitored and evaluated for identification of the possible underlying causes of the reflux, that may be the reason for the PPI use. There are a whole host of potential causes of reflux and other options for treatment.

There have been numerous studies recently published:

It can lead to increase risk of fractures and in a large study from the VA system it has been associated with the risk of premature death

Protein Intake

October 14, 2019 7:08 am

Protein intake requirements change over time following weight loss surgery. This is based on the requirements imposed on our body by a number of variables. These include, activity level, muscle mass, over all health condition to name a few.

A very young muscular athletic male with a BMI or 30 will require much higher protein intake (and absorption) that an inactive older Female with the same BMI. The same young athletic male will require much higher protein intake is he is recovering from a surgery than his baseline.

As we have stated in the past, the protein intake, should be adequate and not excessive. High level of protein intake that are not accounted  for based on muscle mass and activity level, will eventually result in weight gain. The best measure of protein intake in a stable weight patient over 3-4 years post op  is their albumin and protein level. Following your yearly laboratory values at a minimum is an important part of weight loss surgery follow up care.

You also need to adjust protein intake when necessary. Protein needs increase depending on physical needs, infection, healing, pregnancy, surgery, age, injury, etc. Plastic surgery requires higher protein needs for appropriate healing.

Information on protein sources and quality here.

The basic formula for protein intake is 1gm/kg of ideal body weight. The calculator below will provide a guide for the protein into based on your stable weight in lbs.

Overfed But Undernourished

October 01, 2019 11:27 am

Obesity is related to as many as 400,000 deaths each year in the US and it has increasingly been recognized as a risk factor for several nutrient deficiencies. This may seem surprising given the likelihood of over consumption of calories, however these additional calories are not from nutritious sources. One of the main reason for these nutritional deficits is the greater availability of inexpensive foods that are rich in calories and are nutrient deficient. This has led some medical professional to conclude that there is a certain group of people who are overfed but undernourished.  Even with the epidemic of the obesity, there is significant nutritional deficiencies noted.

Obese subjects have increased blood volume, cardiac output, adiposity, lean mass and organ size all of which can influence volume of distribution, in addition, treatment for severe obesity involving surgical procedures can worsen these nutrient deficiencies and in some cases may cause new ones to develop.

This table shows the percentage of population below the estimated average requirement (EAR) by body weight status in adults more tan 19 years old, showing that almost 90 to 100 percent of people including normal weight (NW) are below the EAR of vitamin D and Vitamin E.

Nutrition TableNutritional deficiencies in obese patients may promote the development of chronic diseases including increased insulin resistance, pancreatic B-cell disfunction and diabetes, this is because specific micronutrients are involved in glucose metabolic pathways; There are other chronic diseases related to obesity that are being investigated such as decrease in focal grey matter volume and cognitive impairment or inadequate sleep due to low intake of antioxidant vitamins.

We would like to thank Miguel Rosado, MD for his significant contribution provided for this Blog.

Flagyl

September 25, 2019 9:07 am

Flagyl is sometimes prescribed for excessive gas and diarrhea. It is an antibiotics that works well on certain bacteria that accumulates in the GI tract and contributes to the gas and the bloating. 

These bad bacteria flourish when patients consume significant and excessive fiber and carbohydrates (sugars, salad, pasta etc.) The FIRST line of defense against flatulence, bloating, and diarrhea should be eleminating the culprits in the diet.  This point can not be stressed enough.   Adding a daily dose of yogurt may improve symptoms due to yogurts probiotic benefits. To be beneficial, Yogurt should contain live bacteria cultures, not contain artificial sweeteners or have a high sugar content.

Artificial sweetness also area source of the excessive gas and should be avoided.

The Flagyl eliminates and reduces the bad bacteria. Along with a Probiotic and healthy dietary choices Flagyl can help to significantly improved or eliminate those symptoms of gas and diarrhea.

Before Flagyl is prescribed, it is important that the diet is critically examined to make sure that the carbohydrates and the fiber as source of gas and bloating is minimized or eliminated. Excessive use of medications that may be needed for other infections should be avoided.

Chronic diarrhea should be evaluated to rule out GI infection with C. diff bacteria or other bacteria or parasite.

 

Additional Information on C. Diff (Clostridium Difficile)  and probiotics.